Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM6B | O15054 | 2/20 | 0.39 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.39 |
| ▸ | HIF1AN | Q9NWT6 | 2/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10322403 | 0.80 | KDM4E (0.47) | KDM4EHSD17B10GAAHPGDKDM6B | |
| SCHEMBL31290945 | 0.78 | PARG (0.35) | HSD17B10ALDH1A1NPC1MAPTHTT | |
| SCHEMBL10446512 | 0.76 | KDM4E (0.41) | KDM4EHSD17B10GAAHPGDKDM6B | |
| SCHEMBL10323627 | 0.76 | DYRK1A (0.57) | KDM4EGAAALDH1A1POLBDYRK1A | |
| SCHEMBL10323760 | 0.76 | KDM6B (0.50) | KDM4EHSD17B10GAAHPGDKDM6B | |
| SCHEMBL10323894 | 0.73 | DYRK1A (0.75) | DYRK1ADYRK1B | |
| SCHEMBL10446847 | 0.73 | DYRK1A (0.75) | DYRK1ADYRK1B | |
| SCHEMBL28937216 | 0.72 | CDK2 (0.42) | HSD17B10ALDH1A1NPC1MAPTHTT | |
| SCHEMBL10324034 | 0.72 | KDM4E (0.41) | KDM4EHSD17B10GAAHPGDKDM6B | |
| SCHEMBL29755358 | 0.72 | KDM4E (0.41) | KDM4EHSD17B10GAAHPGDKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098065-A1 | PYRIDO PYRIMIDINES FOR USE AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |
| US-20120184542-A1 | PYRIDO PYRIMIDINES | ANDERSON KEVIN (US) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184542-A1 | PYRIDO PYRIMIDINES | TYMS, TYMP, DPYD | KDM4E 2024/4885HSD17B10 4275/4885GAA 860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.