Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.31 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.31 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13119982 | 0.81 | S1PR1 (0.47) | S1PR1S1PR3PLAUMETTP53 | |
| Hydrochloric Acid SCHEMBL6031240 | 0.80 | S1PR1 (0.46) | S1PR1S1PR3PLAUMETTP53 | |
| SCHEMBL16139588 | 0.77 | S1PR1 (0.42) | S1PR1S1PR3PLAUMETTP53 | |
| SCHEMBL18335163 | 0.77 | S1PR1 (0.41) | S1PR1S1PR3PLAUMETKMT2A | |
| SCHEMBL21598707 | 0.74 | PLAU (0.43) | S1PR1S1PR3PLAUMETTP53 | |
| SCHEMBL18335122 | 0.73 | S1PR1 (0.41) | S1PR1S1PR3PLAUMETKMT2A | |
| SCHEMBL10325419 | 0.72 | AAK1 (0.41) | TP53 | |
| SCHEMBL3616161 | 0.72 | AAK1 (0.39) | ALDH1A1 | |
| SCHEMBL21598694 | 0.71 | S1PR1 (0.39) | S1PR1S1PR3PLAUMETKMT2A | |
| SCHEMBL16654919 | 0.70 | S1PR3 (0.38) | S1PR1S1PR3PLAUMETALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012095781-A1 | INDAZOLE DERIVATIVES AS SODIUM CHANNEL INHIBITORS | PFIZER LIMITED (GB) | 2012-07-19 | — | — | WO | disclosed |