Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 19/20 | 0.50 |
| ▸ | AXL | P30530 | 5/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.47 |
| ▸ | CKS1B | P61024 | 1/20 | 0.47 |
| ▸ | SKP1 | P63208 | 1/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10323273 | 0.91 | MERTK (0.41) | MERTKAXLTYRO3CKS1BSKP1 | |
| SCHEMBL10322642 | 0.90 | MERTK (0.41) | MERTKAXLTYRO3CKS1BSKP1 | |
| SCHEMBL10323155 | 0.88 | MERTK (0.37) | MERTKAXLTYRO3CKS1BSKP1 | |
| SCHEMBL10323281 | 0.86 | MERTK (0.38) | MERTKAXLTYRO3CKS1BSKP1 | |
| SCHEMBL10323426 | 0.86 | MERTK (0.37) | MERTKAXLTYRO3CKS1BSKP1 | |
| SCHEMBL10322562 | 0.85 | MERTK (0.39) | MERTKAXLTYRO3 | |
| SCHEMBL10323252 | 0.84 | MERTK (0.36) | MERTKAXLTYRO3CKS1BSKP1 | |
| SCHEMBL10322433 | 0.83 | MERTK (0.36) | MERTKAXLTYRO3CKS1BSKP1 | |
| SCHEMBL10322947 | 0.81 | CCNT1 (0.35) | MERTKCKS1BSKP1SKP2 | |
| SCHEMBL12185245 | 0.80 | MERTK (0.71) | MERTKAXLTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362023-B2 | Pyrazolo pyrimidines | HOFFMANN-LA ROCHE INC. (US) | 2013-01-29 | — | — | US | disclosed |
| WO-2012098068-A1 | PYRAZOLO PYRIMIDINES AS DYRK1A AND DYRK1B INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |
| US-20120184508-A1 | PYRAZOLO PYRIMIDINES | BIODURO (BEIJING) COMPANY LTD. (CN) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184508-A1 | PYRAZOLO PYRIMIDINES | TYMS, TYMP, TP53 | MERTK 2006/4885AXL 1246/4885TYRO3 1985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.