SCHEMBL10324985

SCHEMBL10324985

CC(C)CNc1ncnc(NC2CC2)n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 7/20 0.43
ESR1 P03372 3/20 0.42
IDH2 P48735 1/20 0.42
EPHX2 P34913 2/20 0.42
MAPK14 Q16539 1/20 0.38
IGF1R P08069 1/20 0.37
IDH1 O75874 1/20 0.36
CYP2C9 P11712 1/20 0.36
NPR3 P17342 1/20 0.36
CYP2C19 P33261 1/20 0.36
CDC7 O00311 1/20 0.35
DAPK3 O43293 1/20 0.35
ROCK2 O75116 1/20 0.35
PRKD3 O94806 1/20 0.35
MAP4K4 O95819 1/20 0.35
PAK4 O96013 1/20 0.35
PIM1 P11309 1/20 0.35
PRKACA P17612 1/20 0.35
CDK2 P24941 1/20 0.35
FLT3 P36888 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28144008 0.78 MAPK8 (0.46) HRH4IDH1CDK2MAPK8MAPK9
SCHEMBL1885183 0.76 MERTK (0.56) FLT3
SCHEMBL10156667 0.75 HRH4 (0.42) HRH4CYP2C9MAPK8
SCHEMBL7759887 0.75 IDH2 (0.43) HRH4ESR1IDH2EPHX2MAPK14
SCHEMBL23244427 0.72 MERTK (0.58) HRH4MAPK14CYP2C9CDK2GSK3B
SCHEMBL1412203 0.72 IRAK4 (0.45) HRH4MAPK14CDC7DAPK3PRKD3
SCHEMBL5966376 0.71 NPSR1 (0.49) HRH4IDH1CYP2C19FLT3MAPK8
SCHEMBL14384546 0.71 KDM4E (0.61) HRH4MAP4K4CDK2
SCHEMBL23175094 0.70 HRH4 (0.66) HRH4
SCHEMBL11922642 0.69 ESR1 (0.50) HRH4ESR1IDH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2663585-A2 OLIGOUREA COMPOUNDS AND METHOD FOR PRODUCING SAME AND USE THEREOF Klockemann, Werner (DE) 2013-11-20 EP disclosed
WO-2012095105-A2 OLIGOUREA COMPOUNDS AND METHOD FOR PRODUCING SAME AND USE THEREOF KLOCKEMANN WERNER (DE) 2012-07-19 WO disclosed