Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 14/20 | 0.54 |
| ▸ | S1PR5 | Q9H228 | 13/20 | 0.54 |
| ▸ | S1PR4 | O95977 | 12/20 | 0.54 |
| ▸ | S1PR3 | Q99500 | 9/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1032578 | 0.82 | S1PR4 (0.54) | S1PR1S1PR5S1PR4S1PR3MAOB | |
| SCHEMBL3822157 | 0.76 | S1PR1 (0.59) | S1PR1S1PR5S1PR4S1PR3PLK1 | |
| SCHEMBL12956548 | 0.76 | S1PR1 (0.63) | S1PR1S1PR5S1PR4S1PR3PLK1 | |
| SCHEMBL3898708 | 0.73 | S1PR1 (0.47) | S1PR1S1PR5S1PR4S1PR3PLK1 | |
| SCHEMBL10088965 | 0.73 | S1PR1 (0.49) | S1PR1S1PR5S1PR4S1PR3PLK1 | |
| SCHEMBL13957338 | 0.72 | S1PR1 (0.48) | S1PR1S1PR5S1PR4S1PR3PLK1 | |
| SCHEMBL13957979 | 0.71 | S1PR1 (0.51) | S1PR1S1PR5S1PR4S1PR3PLK1 | |
| Ammonia Solution, Strong SCHEMBL4951074 | 0.71 | S1PR1 (0.58) | S1PR1S1PR5S1PR4S1PR3PLK1 | |
| SCHEMBL5988215 | 0.71 | PLK1 (0.49) | S1PR1S1PR5S1PR4S1PR3PLK1 | |
| SCHEMBL13598542 | 0.71 | S1PR1 (0.49) | S1PR1S1PR5S1PR4S1PR3PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581509-B1 | 1-(AMINO)INDANES AS EDG RECEPTOR AGONISTS | MERCK SHARP & DOHME (US) | 2011-01-19 | — | — | EP | disclosed |
| EP-1581509-A4 | 1-(AMINO)INDANES AND (1,2-DIHYDRO-3-AMINO)-BENZOFURANS, BENZOTHIOPHENES AND INDOLES AS EDG RECEPTOR AGONISTS | MERCK & CO INC (US) | 2008-04-23 | — | — | EP | disclosed |
| US-7220734-B2 | 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as Edg receptor agonists | MERCK & CO., INC. (US) | 2007-05-22 | — | — | US | disclosed |
| US-20060161005-A1 | 1-(Amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as edg receptor agonists | MERCK SHARP & DOHME CORP. | 2006-07-20 | — | — | US | disclosed |
| EP-1581509-A2 | 1-(AMINO)INDANES AND (1,2-DIHYDRO-3-AMINO)-BENZOFURANS, BENZOTHIOPHENES AND INDOLES AS EDG RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058149-A2 | 1-(AMINO)INDANES AND (1,2-DIHYDRO-3-AMINO)-BENZOFURANS, BENZOTHIOPHENES AND INDOLES | MERCK & CO., INC. (US) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060161005-A1 | 1-(Amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as edg receptor agonists | IDO1, IDO2, EDNRA | S1PR1 518/4885S1PR5 926/4885S1PR4 983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.