SCHEMBL10326643

SCHEMBL10326643

Cc1cc(-c2ccc(F)nc2F)nc(C(C)(C)c2cccc(-n3ccc(C(F)(F)F)n3)n2)c1

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.36
MAPT P10636 3/20 0.36
RAB9A P51151 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
KMT2A Q03164 1/20 0.34
PRMT6 Q96LA8 1/20 0.33
ATM Q13315 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
PDE10A Q9Y233 1/20 0.33
IDH1 O75874 4/20 0.31
IDH2 P48735 2/20 0.31
PHGDH O43175 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10326677 0.92 IDH1 (0.35) NPC1MAPTRAB9ASMN1; SMN2KDM4E
SCHEMBL10326651 0.91 NPC1 (0.37) NPC1MAPTRAB9ASMN1; SMN2KDM4E
SCHEMBL10306791 0.89 KDM4E (0.32) NPC1MAPTRAB9ASMN1; SMN2KDM4E
SCHEMBL11987645 0.80 NPC1 (0.45) NPC1MAPTRAB9ASMN1; SMN2KDM4E
SCHEMBL10326668 0.78 NPC1 (0.33) NPC1MAPTRAB9ASMN1; SMN2KDM4E
SCHEMBL11987006 0.77 MAPT (0.58) NPC1MAPTRAB9ASMN1; SMN2KDM4E
SCHEMBL10306766 0.76 NPC1 (0.37) NPC1MAPTRAB9ASMN1; SMN2KDM4E
SCHEMBL10327009 0.73 MAPT (0.39) NPC1MAPTRAB9ASMN1; SMN2KDM4E
SCHEMBL9007610 0.72 IDH1 (0.36) IDH1IDH2
SCHEMBL10326669 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8216698-B2 Organic electroluminescence device, novel platinum complex compound and novel compound capable of being a ligand thereof FUJIFILM CORPORATION (JP) 2012-07-10 US disclosed
US-8216698-B2 Organic electroluminescence device, novel platinum complex compound and novel compound capable of being a ligand thereof FUJIFILM CORPORATION (JP) 2012-07-10 US disclosed
EP-2112213-A2 Organic electroluminescence device, novel platinum complex compound and novel compound capable of being a ligand thereof FUJIFILM Corporation (JP) 2009-10-28 EP disclosed
US-20090261721-A1 ORGANIC ELECTROLUMINESCENCE DEVICE, NOVEL PLATINUM COMPLEX COMPOUND AND NOVEL COMPOUND CAPABLE OF BEING A LIGAND THEREOF FUJIFILM CORPORATION (JP) 2009-10-22 US disclosed
US-20090261721-A1 ORGANIC ELECTROLUMINESCENCE DEVICE, NOVEL PLATINUM COMPLEX COMPOUND AND NOVEL COMPOUND CAPABLE OF BEING A LIGAND THEREOF FUJIFILM CORPORATION (JP) 2009-10-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090261721-A1 ORGANIC ELECTROLUMINESCENCE DEVICE, NOVEL PLATINUM COMPLEX COMPOUND AND NOVEL COMPOUND CAPABLE OF BEING A LIGAND THEREOF L1CAM, PDCD1LG2, CD274 NPC1 4278/4885MAPT 2945/4885RAB9A 2246/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.