SCHEMBL10328153

SCHEMBL10328153

CCOc1ccc(Cc2cc([C@@H]3O[C@H](COC(C)=O)[C@@H](C)[C@H](OC(C)=O)[C@H]3OC(C)=O)ccc2Cl)cc1

nearest known ligand 0.56

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 18/20 0.56
SLC5A1 P13866 8/20 0.56
ADRA2A P08913 1/20 0.56
SLC5A11 Q8WWX8 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18511213 1.00 SLC5A2 (0.56) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL18511220 1.00 SLC5A2 (0.56) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL10177079 0.95 SLC5A2 (0.56) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL13626285 0.93 SLC5A2 (0.56) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL10228164 0.93 SLC5A2 (0.58) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL15030927 0.93 SLC5A2 (0.58) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL18214898 0.93 SLC5A2 (0.58) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL19182955 0.93 SLC5A2 (0.58) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL16730394 0.93 SLC5A2 (0.58) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL18522185 0.93 SLC5A2 (0.58) SLC5A2SLC5A1ADRA2ASLC5A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9895389-B2 Glycoside derivatives and uses thereof NOVARTIS AG (CH) 2018-02-20 US disclosed
US-20170042925-A1 GLYCOSIDE DERIVATIVES AND USES THEREOF NOVARTIS AG (CH) 2017-02-16 US disclosed
US-20150141354-A1 GLYCOSIDE DERIVATIVES AND USES THEREOF NOVARTIS AG (CH) 2015-05-21 US disclosed
US-20140274921-A1 GLYCOSIDE DERIVATIVES AND USES THEREOF NOVARTIS AG (CH) 2014-09-18 US disclosed
US-8466114-B2 Glycoside derivatives and uses thereof NOVARTIS AG (CH) 2013-06-18 US disclosed
US-20120178680-A1 GLYCOSIDE DERIVATIVES AND USES THEREOF NOVARTIS AG (CH) 2012-07-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170042925-A1 GLYCOSIDE DERIVATIVES AND USES THEREOF SLC5A1, SLC5A2, SLC2A1 SLC5A2 2/4885SLC5A1 1/4885ADRA2A 3145/4885
US-20120178680-A1 GLYCOSIDE DERIVATIVES AND USES THEREOF SLC5A1, SLC5A2, SLC2A1 SLC5A2 2/4885SLC5A1 1/4885ADRA2A 3145/4885
US-20150141354-A1 GLYCOSIDE DERIVATIVES AND USES THEREOF SLC5A1, SLC5A2, SLC2A1 SLC5A2 2/4885SLC5A1 1/4885ADRA2A 3145/4885
US-20140274921-A1 GLYCOSIDE DERIVATIVES AND USES THEREOF SLC5A1, SLC5A2, SLC2A1 SLC5A2 2/4885SLC5A1 1/4885ADRA2A 3145/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.