Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.70 |
| ▸ | MAPK8 | P45983 | 14/20 | 0.70 |
| ▸ | MAPK9 | P45984 | 14/20 | 0.70 |
| ▸ | MAPK10 | P53779 | 14/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 13/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5449305 | 0.86 | PIK3CA (0.70) | PIK3CAMAPK8MAPK9MAPK10MAPK1 | |
| SCHEMBL5441554 | 0.85 | PIK3CA (0.71) | PIK3CAMAPK8MAPK9MAPK10MAPK1 | |
| SCHEMBL5455686 | 0.85 | PIK3CA (0.71) | PIK3CAMAPK8MAPK9MAPK10MAPK1 | |
| SCHEMBL10328053 | 0.84 | PIK3CA (0.64) | PIK3CAMAPK8MAPK9MAPK10MAPK1 | |
| SCHEMBL5454900 | 0.83 | PIK3CA (0.83) | PIK3CAMAPK8MAPK9MAPK10MAPK1 | |
| SCHEMBL5447520 | 0.83 | PIK3CA (1.00) | PIK3CAMAPK8MAPK9MAPK10MAPK1 | |
| SCHEMBL14506618 | 0.83 | PIK3CA (1.00) | PIK3CAMAPK8MAPK9MAPK10MAPK1 | |
| SCHEMBL5622877 | 0.83 | PIK3CA (0.76) | PIK3CAMAPK8MAPK9MAPK10MAPK1 | |
| SCHEMBL5623757 | 0.82 | PIK3CA (0.83) | PIK3CAMAPK8MAPK9MAPK10MAPK1 | |
| SCHEMBL10328380 | 0.82 | PIK3CA (0.61) | PIK3CAMAPK8MAPK9MAPK10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962854-B1 | PYRIDOPYRAZINE DERIVATIVES AND USE THEREOF AS MODULATORS OF THE SIGNAL TRANSDUCTION PATHS | TERNA ZENTARIS GMBH (DE) | 2015-05-06 | — | — | EP | disclosed |
| US-8217042-B2 | Pyridopyrazines and their use as modulators of kinases | ZENTARIS GMBH (DE) | 2012-07-10 | — | — | US | disclosed |
| US-8217042-B2 | Pyridopyrazines and their use as modulators of kinases | ZENTARIS GMBH (DE) | 2012-07-10 | — | — | US | disclosed |