Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.37 |
| ▸ | CDK2 | P24941 | 5/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.33 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | WNT3A | P56704 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL41447 | 0.90 | MTOR (0.43) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL10328351 | 0.88 | MTOR (0.45) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL10210938 | 0.83 | MTOR (0.43) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL15007449 | 0.83 | MTOR (0.42) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL15026255 | 0.80 | MTOR (0.43) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL6890659 | 0.80 | MTOR (0.52) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL6891460 | 0.80 | MTOR (0.65) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL30716 | 0.80 | MTOR (0.43) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL2688635 | 0.79 | MTOR (0.43) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL7883621 | 0.79 | MTOR (0.43) | MTORRPTORMLST8CHEK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178744-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178744-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | MTOR, RICTOR, RPTOR | MTOR 1/4885RPTOR 3/4885MLST8 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.