Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 15/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11897208 | 0.94 | HCRTR1 (0.47) | HCRTR1CYP3A4PRMT5HCRTR2NAMPT | |
| SCHEMBL2686272 | 0.94 | HCRTR1 (0.47) | HCRTR1CYP3A4PRMT5HCRTR2NAMPT | |
| SCHEMBL933562 | 0.90 | HCRTR1 (0.46) | HCRTR1CYP3A4PRMT5HCRTR2 | |
| SCHEMBL992222 | 0.85 | CYP3A4 (0.45) | HCRTR1CYP3A4PRMT5HCRTR2 | |
| SCHEMBL935146 | 0.85 | CYP3A4 (0.45) | HCRTR1CYP3A4PRMT5HCRTR2 | |
| SCHEMBL15229283 | 0.84 | HCRTR1 (0.58) | HCRTR1PRMT5HCRTR2 | |
| SCHEMBL934269 | 0.83 | CYP3A4 (0.40) | HCRTR1CYP3A4PRMT5HCRTR2NAMPT | |
| SCHEMBL2687069 | 0.83 | CYP3A4 (0.42) | HCRTR1CYP3A4PRMT5HCRTR2DPP4 | |
| SCHEMBL2687070 | 0.83 | CYP3A4 (0.42) | HCRTR1CYP3A4PRMT5HCRTR2DPP4 | |
| SCHEMBL11896988 | 0.81 | CYP3A4 (0.55) | HCRTR1CYP3A4HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2275421-A1 | Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction | Rottapharm S.p.A. (IT) | 2011-01-19 | — | — | EP | disclosed |