Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.59 |
| ▸ | BACE2 | Q9Y5Z0 | 18/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10328723 | 0.94 | BACE1 (0.66) | BACE1BACE2KCNH2 | |
| SCHEMBL10328794 | 0.92 | BACE1 (0.61) | BACE1BACE2KCNH2 | |
| SCHEMBL10328969 | 0.92 | BACE1 (0.59) | BACE1BACE2KCNH2 | |
| SCHEMBL10328732 | 0.90 | BACE1 (0.66) | BACE1BACE2KCNH2 | |
| Verubecestat SCHEMBL10328722 | 0.90 | BACE1 (0.66) | BACE1BACE2KCNH2 | |
| SCHEMBL10328829 | 0.89 | BACE1 (0.56) | BACE1BACE2KCNH2 | |
| SCHEMBL10329003 | 0.88 | BACE1 (0.55) | BACE1BACE2KCNH2 | |
| SCHEMBL10328727 | 0.88 | BACE1 (0.55) | BACE1BACE2KCNH2 | |
| SCHEMBL10328733 | 0.88 | BACE1 (0.66) | BACE1BACE2KCNH2 | |
| SCHEMBL17208596 | 0.88 | BACE1 (0.56) | BACE1BACE2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120183563-A1 | IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS AND THEIR USE | MERCK SHARP & DOHME LLC | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120183563-A1 | IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS AND THEIR USE | BACE1, BACE2, APP | BACE1 1/4885BACE2 2/4885KCNH2 2853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.