Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 16/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 14/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10331264 | 0.93 | DYRK1A (0.66) | DYRK1ADYRK1B | |
| SCHEMBL10331378 | 0.92 | DYRK1A (0.62) | DYRK1ADYRK1B | |
| SCHEMBL10331222 | 0.91 | DYRK1A (0.66) | DYRK1ADYRK1BROCK2ROCK1 | |
| SCHEMBL10331210 | 0.87 | DYRK1A (0.55) | DYRK1ADYRK1BROCK2ROCK1 | |
| SCHEMBL10331214 | 0.87 | DYRK1A (0.64) | DYRK1ADYRK1B | |
| SCHEMBL10331185 | 0.86 | DYRK1A (0.75) | DYRK1ADYRK1B | |
| SCHEMBL10331282 | 0.84 | DYRK1A (0.64) | DYRK1ADYRK1B | |
| SCHEMBL10331303 | 0.84 | DYRK1A (0.76) | DYRK1ADYRK1B | |
| SCHEMBL10321271 | 0.84 | DYRK1A (0.72) | DYRK1ADYRK1B | |
| SCHEMBL10321742 | 0.84 | DYRK1A (0.61) | DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098066-A1 | 1,6- AND 1,8-NAPHTHYRIDINES USEFUL AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |
| US-20120184562-A1 | 1,6- AND 1,8-NAPHTHYRIDINES | LUK KIN-CHUN (US) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184562-A1 | 1,6- AND 1,8-NAPHTHYRIDINES | PSEN1, BRCA1, PSEN2 | DYRK1A 1366/4885DYRK1B 2109/4885PIK3CA 1765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.