Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.82 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.82 |
| ▸ | MAPT | P10636 | 4/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.82 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.82 |
| ▸ | LMNA | P02545 | 1/20 | 0.82 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.82 |
| ▸ | GALR3 | O60755 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699653 | 0.95 | PDE3B (0.76) | PDE3BPDE3AMAPTALDH1A1SLFN12 | |
| SCHEMBL29491026 | 0.90 | PDE3B (1.00) | PDE3BPDE3AMAPTALDH1A1SLFN12 | |
| SCHEMBL16156971 | 0.90 | PDE3B (1.00) | PDE3BPDE3AMAPTALDH1A1SLFN12 | |
| SCHEMBL16156956 | 0.90 | PDE3B (1.00) | PDE3BPDE3AMAPTALDH1A1SLFN12 | |
| SCHEMBL29609389 | 0.90 | PDE3B (1.00) | PDE3BPDE3AMAPTALDH1A1SLFN12 | |
| SCHEMBL29491012 | 0.90 | PDE3B (1.00) | PDE3BPDE3AMAPTALDH1A1SLFN12 | |
| SCHEMBL10333846 | 0.89 | GALR3 (0.73) | PDE3BPDE3AMAPTALDH1A1SLFN12 | |
| SCHEMBL10333665 | 0.81 | GALR3 (1.00) | PDE3BPDE3AMAPTALDH1A1SLFN12 | |
| SCHEMBL17446945 | 0.79 | MAPT (0.79) | PDE3BPDE3AMAPTALDH1A1SLFN12 | |
| SCHEMBL17446927 | 0.79 | MAPT (0.79) | PDE3BPDE3AMAPTALDH1A1SLFN12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4954499-A | Pyridazinone derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-09-04 | — | — | US | disclosed |
| EP-0279283-A2 | Pyridazinone derivatives | MERCK PATENT GmbH (DE) | 1988-08-24 | — | — | EP | disclosed |