Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 16/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 16/20 | 0.65 |
| ▸ | PDE4A | P27815 | 6/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9367299 | 0.85 | PDE3B (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9367616 | 0.82 | PDE3B (0.57) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9371436 | 0.82 | PDE3B (0.57) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9367690 | 0.81 | PDE3B (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Imazodan SCHEMBL148436 | 0.80 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9368365 | 0.79 | PDE3B (0.52) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Imazodan SCHEMBL124243 | 0.79 | PDE3B (0.97) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9367527 | 0.79 | PDE3B (0.55) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9367104 | 0.79 | PDE3B (0.54) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9368490 | 0.78 | PDE3B (0.53) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4925845-A | HYPOTENSIVE AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-05-15 | — | — | US | disclosed |