Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10925949 | 0.77 | TDP1 (0.40) | TSHRS1PR4MAPTNPC1MAPK1 | |
| SCHEMBL9363986 | 0.75 | TDP1 (0.41) | TSHRS1PR4MAPTNPC1MAPK1 | |
| SCHEMBL9367243 | 0.75 | TDP1 (0.44) | TSHRS1PR4MAPTNPC1MAPK1 | |
| SCHEMBL9371041 | 0.75 | TDP1 (0.41) | TSHRCYP2C19HPGDMAPTNPC1 | |
| SCHEMBL10738118 | 0.74 | TDP1 (0.38) | TSHRCYP2C19S1PR4HPGDMAPT | |
| SCHEMBL9662442 | 0.74 | TDP1 (0.37) | TSHRS1PR4HPGDMAPTNPC1 | |
| SCHEMBL11083979 | 0.74 | TDP1 (0.37) | TSHRCYP2D6CYP2C19HIF1AS1PR4 | |
| SCHEMBL10705611 | 0.73 | TDP1 (0.36) | TSHRS1PR4NPC1MAPK1TDP1 | |
| SCHEMBL11121121 | 0.72 | SMN1; SMN2 (0.37) | TSHRHPGDMAPTNPC1LMNA | |
| SCHEMBL10761816 | 0.72 | KMT2A (0.35) | TSHRCYP2C19HPGDMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2096571-A | — | — | None | — | — | JP | disclosed |
| JP-H0296571-A | 1-(2-PHENYLETHYL)-1H-1,2,4-TRIAZOLE DERIVATIVE | MORISHITA PHARMACEUT CO LTD | 1990-04-09 | — | — | JP | disclosed |