SCHEMBL1034252

SCHEMBL1034252

CCCCc1c(CCC(=O)c2ccc(CCC(=O)O)c(C)c2)sc2cc(C(F)(F)F)ccc12

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 8/20 0.41
PPARA Q07869 6/20 0.41
PPARG P37231 5/20 0.41
PTGDR2 Q9Y5Y4 2/20 0.40
S1PR1 P21453 1/20 0.37
FFAR4 Q5NUL3 3/20 0.34
FFAR1 O14842 1/20 0.34
FFAR2 O15552 1/20 0.34
FRK P42685 1/20 0.33
CAMK2B Q13554 1/20 0.33
CAMK2G Q13555 1/20 0.33
CAMK2D Q13557 1/20 0.33
PLK1 P53350 1/20 0.33
CYP1A2 P05177 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1033815 0.95 PPARD (0.42) PPARDPPARAPPARGPTGDR2S1PR1
SCHEMBL1033639 0.93 PPARD (0.42) PPARDPPARAPPARGPTGDR2S1PR1
SCHEMBL1033887 0.91 PPARD (0.36) PPARDPPARAPPARGPTGDR2FRK
SCHEMBL27988457 0.91 PTGDR2 (0.37) PPARDPPARAPPARGPTGDR2S1PR1
SCHEMBL1033867 0.89 PPARD (0.41) PPARDPPARAPPARGPTGDR2FFAR4
SCHEMBL1034963 0.88 PPARD (0.44) PPARDPPARAPPARGPTGDR2FFAR4
SCHEMBL1033328 0.86 PPARD (0.36) PPARDPPARAPPARGPTGDR2FRK
SCHEMBL1033622 0.85 PPARD (0.42) PPARDPPARAPPARGPTGDR2FFAR4
SCHEMBL1035843 0.83 PPARD (0.35) PPARDPPARAPPARGPTGDR2FRK
SCHEMBL27988157 0.82 PTGDR2 (0.36) PPARDPPARAPPARGPTGDR2S1PR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2277874-B1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR NIPPON CHEMIPHAR CO (JP) 2018-06-27 EP claimed
CN-102083810-B Activator of peroxisome proliferator activated receptor NIPPON CHEMIPHAR CO.,LTD. (JP) 2014-10-29 CN claimed
US-8648208-B2 Activating agent for peroxisome proliferator activated receptor NIPPON CHEMIPHAR CO. LTD. (JP) 2014-02-11 US claimed
CN-102083810-A Activator of peroxisome proliferator activated receptor NIPPON CHEMIPHAR CO 2011-06-01 CN claimed
US-20110098480-A1 ACTIVATING AGENT FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR NIPPON CHEMIPHAR CO. LTD. (JP) 2011-04-28 US claimed
EP-2277874-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR Nippon Chemiphar Co., Ltd. (JP) 2011-01-26 EP claimed
US-20190255022-A1 WOUND-HEALING AGENT NIPPON CHEMIPHAR CO., LTD. (JP) 2019-08-22 US disclosed
EP-3456327-A1 WOUND-HEALING AGENT Nippon Chemiphar Co., Ltd. (JP) 2019-03-20 EP disclosed
EP-3424917-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR Nippon Chemiphar Co., Ltd. (JP) 2019-01-09 EP disclosed
EP-2277874-B1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR NIPPON CHEMIPHAR CO (JP) 2018-06-27 EP disclosed
CN-102083810-B Activator of peroxisome proliferator activated receptor NIPPON CHEMIPHAR CO.,LTD. (JP) 2014-10-29 CN disclosed
US-8648208-B2 Activating agent for peroxisome proliferator activated receptor NIPPON CHEMIPHAR CO. LTD. (JP) 2014-02-11 US disclosed
CN-102083810-A Activator of peroxisome proliferator activated receptor NIPPON CHEMIPHAR CO 2011-06-01 CN disclosed
US-20110098480-A1 ACTIVATING AGENT FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR NIPPON CHEMIPHAR CO. LTD. (JP) 2011-04-28 US disclosed
EP-2277874-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR Nippon Chemiphar Co., Ltd. (JP) 2011-01-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190255022-A1 WOUND-HEALING AGENT PPARG, PPARA, PPARD PPARD 3/4885PPARA 2/4885PPARG 1/4885
US-20110098480-A1 ACTIVATING AGENT FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR PPARA, PPARG, PPARD PPARD 3/4885PPARA 1/4885PPARG 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.