Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Homoserine Lactone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Homoserine Lactone SCHEMBL1536657 | 1.00 | — | — | |
| Homoserine Lactone SCHEMBL7217249 | 1.00 | — | — | |
| Homoserine Lactone SCHEMBL79968 | 0.97 | — | — | |
| Homoserine Lactone SCHEMBL79466 | 0.97 | — | — | |
| Homoserine Lactone SCHEMBL79969 | 0.97 | — | — | |
| SCHEMBL731550 | 0.97 | TSHR (0.32) | — | |
| Homoserine Lactone SCHEMBL1402931 | 0.95 | — | — | |
| Homoserine Lactone SCHEMBL1147212 | 0.95 | — | — | |
| Homoserine Lactone SCHEMBL787339 | 0.95 | — | — | |
| Homoserine Lactone SCHEMBL15227619 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 187 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107973733-B | Method for preparing selenomethionine | 四川新一美生物科技有限公司 | 2020-04-17 | — | — | CN | claimed |
| US-20240124408-A1 | Substituted Cyclohexanecarboxamides, Their Preparation and Their Therapeutic Application | SANOFI (FR) | 2024-04-18 | — | — | US | disclosed |
| CN-115677548-B | Efficient synthesis method of selenomethionine | 湖南农业大学 | 2024-04-09 | — | — | CN | disclosed |
| EP-4263493-A1 | SUBSTITUTED CYCLOHEXANECARBOXAMIDES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | Sanofi (FR) | 2023-10-25 | — | — | EP | disclosed |
| WO-2023097207-A1 | SYNTHETIC PROCESS FOR PRODUCTION OF MODIFIED GCC RECEPTOR AGONISTS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2023-06-01 | — | — | WO | disclosed |
| US-20230138795-A1 | DOPAMINE-B-HYDROXYLASE INHIBITORS | BIAL PORTELA & CA SA (PT) | 2023-05-04 | — | — | US | disclosed |
| US-11434242-B2 | Dopamine-b-hydroxylase inhibitors | BIAL—PORTELA & CA, S.A. (PT) | 2022-09-06 | — | — | US | disclosed |
| WO-2022133027-A1 | SUBSTITUTED CYCLOHEXANECARBOXAMIDES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2022-06-23 | — | — | WO | disclosed |
| CN-111138332-B | Seleno-glycyrrhetinic acid, preparation method and application thereof | 山东兴安动物药业有限公司 | 2021-10-26 | — | — | CN | disclosed |
| US-20210171528-A1 | DOPAMINE-B-HYDROXYLASE INHIBITORS | BIAL - PORTELA & CA, S.A. (PT) | 2021-06-10 | — | — | US | disclosed |
| EP-0151964-A2 | New derivatives of alpha-amino-gamma-butyrolactone, method for the preparation thereof and pharmaceutical compositions containing them | Laboratorio Farmaceutico C.T. s.r.l. (IT) | 1985-08-21 | — | — | EP | disclosed |
| US-4474801-A | ALCOHOLISM | ISTITUTO CHEMIOTERAPICO ITALIANO, SPA (IT) | 1984-10-02 | — | — | US | disclosed |
| US-4290957-A | SWEETENERS | DYNAPOL (US) | 1981-09-22 | — | — | US | disclosed |
| US-4267165-A | Comestibles sweetened with alpha amino acid dihydrochalcones | DYNAPOL (US) | 1981-05-12 | — | — | US | disclosed |
| US-4226804-A | ARTIFICIAL SWEETENER | DYNAPOL (US) | 1980-10-07 | — | — | US | disclosed |
| US-4180579-A | 2-Substituted-1H-benz[de]-isoquinoline-1,3(2H)-diones | E. R. SQUIBB & SONS, INC. (US) | 1979-12-25 | — | — | US | disclosed |
| US-4170651-A | ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1979-10-09 | — | — | US | disclosed |
| US-4115555-A | ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1978-09-19 | — | — | US | disclosed |
| US-4051246-A | ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1977-09-27 | — | — | US | disclosed |
| US-3968233-A | α-Amino-γ-butyrolactones as sedatives | ISTITUTO CHEMIOTERAPICO ITALIANO (IT) | 1976-07-06 | — | — | US | disclosed |