Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | HMGCR | P04035 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | CCKAR | P32238 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10345248 | 1.00 | NR4A2 (0.41) | NR4A2PDE4DNR1I2HMGCRCYP2C9 | |
| SCHEMBL8953101 | 0.89 | HMGCR (0.40) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL8953087 | 0.89 | HMGCR (0.40) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL8953104 | 0.89 | HMGCR (0.40) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL8953090 | 0.89 | HMGCR (0.40) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL10345348 | 0.88 | NR4A2 (0.42) | NR4A2PDE4DNR1I2HMGCRCYP2C9 | |
| SCHEMBL8952773 | 0.87 | HMGCR (0.39) | HMGCR | |
| SCHEMBL8952771 | 0.87 | HMGCR (0.38) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL8952776 | 0.87 | HMGCR (0.38) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL8952759 | 0.86 | ESR1 (0.39) | HMGCRTBXA2RADRA1AESR1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0356788-A2 | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1990-03-07 | — | — | EP | disclosed |