Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 16/20 | 0.73 |
| ▸ | PDE1B | Q01064 | 16/20 | 0.73 |
| ▸ | PDE1C | Q14123 | 16/20 | 0.73 |
| ▸ | ESR1 | P03372 | 3/20 | 0.67 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | GBA1 | P04062 | 1/20 | 0.62 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | PRKCG | P05129 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | PRKCB | P05771 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10608838 | 1.00 | PDE1A (0.73) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL10349388 | 1.00 | PDE1A (0.73) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL8767689 | 0.95 | PDE1A (0.76) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL8767710 | 0.95 | PDE1A (0.76) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL8767701 | 0.95 | PDE1A (0.76) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL8768173 | 0.94 | PDE1A (0.76) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL8768184 | 0.94 | PDE1A (0.76) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL8768178 | 0.94 | PDE1A (0.76) | PDE1APDE1BPDE1CESR1ESR2 | |
| SCHEMBL10796138 | 0.93 | CYP19A1 (0.74) | ESR1ESR2CYP3A4CYP19A1MEN1 | |
| SCHEMBL10796143 | 0.93 | CYP19A1 (0.74) | ESR1ESR2CYP3A4CYP19A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260066-B1 | TAMOXIFEN DERIVATIVES | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1990-05-09 | — | — | EP | disclosed |
| US-4839155-A | Iodotamoxifen derivatives and use for estrogen receptor-positive breast cancer detection and therapy | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1989-06-13 | — | — | US | disclosed |
| EP-0260066-A1 | Tamoxifen derivatives | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1988-03-16 | — | — | EP | disclosed |