Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.81 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | NPY1R | P25929 | 1/20 | 0.63 |
| ▸ | NPY2R | P49146 | 1/20 | 0.63 |
| ▸ | PDE3B | Q13370 | 12/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.62 |
| ▸ | PDE4A | P27815 | 6/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL927560 | 0.92 | SMN1; SMN2 (0.70) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL9687996 | 0.92 | SMN1; SMN2 (0.70) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL930230 | 0.90 | SMN1; SMN2 (0.68) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL7273533 | 0.90 | SMN1; SMN2 (0.68) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL11035016 | 0.90 | SMN1; SMN2 (0.68) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL6331085 | 0.90 | SMN1; SMN2 (0.68) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL8302890 | 0.90 | SMN1; SMN2 (0.68) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL2846257 | 0.90 | SMN1; SMN2 (0.68) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL10556720 | 0.90 | SMN1; SMN2 (0.68) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL2798028 | 0.90 | SMN1; SMN2 (1.00) | SMN1; SMN2KCNH2LMNAMAPTNPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208517-B1 | 6-OXO-PYRIDAZINYL COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-09-12 | — | — | EP | claimed |
| US-4904664-A | INOTROPIC, BRONCHODILATOR, AND VASODILATOR AGENTS; CONGESTIVE HEART FAILURE; CARDIOVASCULAR DISORDERS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-02-27 | — | — | US | claimed |
| EP-0208517-B1 | 6-OXO-PYRIDAZINYL COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-09-12 | — | — | EP | disclosed |
| US-4904664-A | INOTROPIC, BRONCHODILATOR, AND VASODILATOR AGENTS; CONGESTIVE HEART FAILURE; CARDIOVASCULAR DISORDERS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-02-27 | — | — | US | disclosed |
| EP-0208517-A2 | 6-Oxo-pyridazinyl compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-01-14 | — | — | EP | disclosed |