Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | IGF1R | P08069 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.49 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7170786 | 0.90 | MAPT (0.68) | MAPTL3MBTL1MAPK1KDM4ELMNA | |
| SCHEMBL10353552 | 0.88 | MAPT (0.76) | MAPTL3MBTL1MAPK1TDP1IDO1 | |
| SCHEMBL1748266 | 0.84 | MAPT (0.51) | MAPTL3MBTL1MAPK1TDP1EGFR | |
| SCHEMBL95561 | 0.84 | MAPT (1.00) | MAPTL3MBTL1MAPK1TDP1IDO1 | |
| SCHEMBL102602 | 0.83 | MAPT (0.77) | MAPTL3MBTL1MAPK1TDP1EGFR | |
| SCHEMBL10353546 | 0.83 | MAPT (0.72) | MAPTL3MBTL1MAPK1TDP1IDO1 | |
| SCHEMBL10353608 | 0.83 | MAPT (0.59) | MAPTL3MBTL1MAPK1KDM4EPRKCQ | |
| SCHEMBL13941340 | 0.83 | MAPT (0.59) | MAPTL3MBTL1MAPK1TDP1PRKCQ | |
| SCHEMBL7164868 | 0.81 | MAPT (0.84) | MAPTL3MBTL1MAPK1TDP1IDO1 | |
| SCHEMBL6474912 | 0.81 | MAPT (0.69) | MAPTL3MBTL1TDP1RECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0190817-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-09-05 | — | — | EP | disclosed |
| US-4857540-A | 1-SUBSTITUTED-2-MERCAPTO-(OR AMINOMETHYL-)BENZAMIDAZOLE COMPOUNDS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-08-15 | — | — | US | disclosed |
| US-4728741-A | DOPAMINE BETA-HYDROXYLASE INHIBITOR | SMITHKLINE BECKMAN CORPORATION (US) | 1988-03-01 | — | — | US | disclosed |