Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.58 |
| ▸ | BTK | Q06187 | 4/20 | 0.57 |
| ▸ | FAM20C | Q8IXL6 | 1/20 | 0.57 |
| ▸ | ITK | Q08881 | 5/20 | 0.57 |
| ▸ | EGFR | P00533 | 4/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.54 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 7/20 | 0.52 |
| ▸ | GSK3A | P49840 | 4/20 | 0.51 |
| ▸ | PLK4 | O00444 | 3/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 3/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.51 |
| ▸ | INSR | P06213 | 3/20 | 0.51 |
| ▸ | LCK | P06239 | 3/20 | 0.51 |
| ▸ | FYN | P06241 | 3/20 | 0.51 |
| ▸ | CSF1R | P07333 | 3/20 | 0.51 |
| ▸ | IGF1R | P08069 | 3/20 | 0.51 |
| ▸ | ROS1 | P08922 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12726303 | 0.93 | EGFR (0.65) | SYKBTKITKEGFRADORA3 | |
| Hydrochloric Acid SCHEMBL1037848 | 0.92 | EGFR (0.64) | SYKBTKITKEGFRADORA3 | |
| SCHEMBL1037441 | 0.92 | SYK (0.56) | SYKBTKFAM20CITKEGFR | |
| SCHEMBL1221693 | 0.91 | SYK (0.64) | SYKBTKITKEGFRADORA3 | |
| SCHEMBL1038608 | 0.90 | PTK2 (0.57) | SYKBTKITKEGFRADORA3 | |
| SCHEMBL1038905 | 0.88 | SYK (0.54) | SYKBTKFAM20CITKEGFR | |
| SCHEMBL12894667 | 0.86 | SYK (0.62) | SYKBTKFAM20CITKEGFR | |
| SCHEMBL1038876 | 0.86 | SYK (0.56) | SYKBTKITKEGFRADORA3 | |
| SCHEMBL1222113 | 0.85 | EGFR (0.68) | SYKBTKITKEGFRADORA3 | |
| SCHEMBL1033746 | 0.85 | SYK (0.55) | SYKBTKFAM20CITKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098288-A1 | SULFONAMIDES AS ZAP-70 INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | US | claimed |
| EP-2276747-A1 | SULFONAMIDES AS ZAP-70 INHIBITORS | Cellzome Limited (GB) | 2011-01-26 | — | — | EP | claimed |
| WO-2009112490-A1 | SULFONAMIDES AS ZAP-70 INHIBITORS | CELLZOME LIMITED (GB) | 2009-09-17 | — | — | WO | claimed |
| US-20110098288-A1 | SULFONAMIDES AS ZAP-70 INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | US | disclosed |
| US-20110098288-A1 | SULFONAMIDES AS ZAP-70 INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | US | disclosed |
| EP-2276747-A1 | SULFONAMIDES AS ZAP-70 INHIBITORS | Cellzome Limited (GB) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009112490-A1 | SULFONAMIDES AS ZAP-70 INHIBITORS | CELLZOME LIMITED (GB) | 2009-09-17 | — | — | WO | disclosed |
| WO-2009112490-A1 | SULFONAMIDES AS ZAP-70 INHIBITORS | CELLZOME LIMITED (GB) | 2009-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098288-A1 | SULFONAMIDES AS ZAP-70 INHIBITORS | ZAP70, SYK, LCK | SYK 2/4885BTK 4/4885FAM20C 762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.