Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 6/20 | 0.62 |
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | HTR2C | P28335 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | MTOR | P42345 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | DRD2 | P14416 | 2/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.62 |
| ▸ | HTR2A | P28223 | 2/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL10154 | 0.87 | CACNA2D1 (0.58) | SLC6A2SLC6A4SLC6A3KMT2ACYP2D6 | |
| Oxalic Acid SCHEMBL3993 | 0.87 | CACNA2D1 (0.58) | SLC6A2SLC6A4SLC6A3KMT2ACYP2D6 | |
| Oxalic Acid SCHEMBL3799 | 0.86 | SLC6A4 (0.58) | SLC6A2SLC6A4SLC6A3KMT2ACYP2D6 | |
| Oxalic Acid SCHEMBL10359897 | 0.84 | SLC6A4 (0.62) | SLC6A4HRH3SLC7A5CACNA2D1 | |
| Fluoxetine SCHEMBL8722258 | 0.84 | SLC6A4 (0.88) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| Oxalic Acid SCHEMBL3980 | 0.81 | SLC6A4 (0.64) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| Oxalic Acid SCHEMBL3554 | 0.80 | SLC6A4 (0.62) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| Fluoxetine SCHEMBL28120450 | 0.80 | SLC6A4 (0.72) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| Fluoxetine SCHEMBL28120451 | 0.80 | SLC6A4 (0.72) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| Oxalic Acid SCHEMBL4739531 | 0.80 | SLC6A4 (0.72) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |