⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23079318 | 0.75 | HRH1 (0.33) | — | |
| SCHEMBL2096550 | 0.75 | HRH1 (0.30) | — | |
| SCHEMBL2096548 | 0.74 | — | — | |
| SCHEMBL28170638 | 0.73 | — | — | |
| SCHEMBL12310544 | 0.71 | — | — | |
| SCHEMBL9804376 | 0.70 | — | — | |
| SCHEMBL28934730 | 0.70 | — | — | |
| SCHEMBL25209792 | 0.70 | — | — | |
| SCHEMBL20128447 | 0.67 | TAAR1 (0.37) | — | |
| SCHEMBL2256862 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0267986-B1 | \"(2-AMINO-4-ARYL-THIAZOLE-5-YL)ETHANOLS AND THEIR DERIVATIVES HAVING DIURETIC ACTIVITY AND METHODS FOR PREPARING THE SAME | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1990-11-22 | — | — | EP | disclosed |
| EP-0267986-A1 | \"(2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1988-05-25 | — | — | EP | disclosed |