Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 19/20 | 1.00 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.69 |
| ▸ | MAOA | P21397 | 1/20 | 0.69 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.67 |
| ▸ | AR | P10275 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10360819 | 1.00 | MAOB (1.00) | MAOBCYP19A1MAOAPSMB5KDM4E | |
| SCHEMBL9825807 | 0.88 | MAOB (0.78) | MAOBCYP19A1MAOAPSMB5KDM4E | |
| SCHEMBL31060428 | 0.84 | MAOB (1.00) | MAOBCYP19A1 | |
| SCHEMBL2474549 | 0.83 | MAOB (1.00) | MAOBCYP19A1KDM4EADORA3AR | |
| SCHEMBL2474548 | 0.83 | MAOB (1.00) | MAOBCYP19A1KDM4EADORA3AR | |
| SCHEMBL11383085 | 0.83 | MAOB (0.71) | MAOBCYP19A1MAOAPSMB5KDM4E | |
| SCHEMBL1933329 | 0.82 | MAOB (0.69) | MAOBCYP19A1MAOAPSMB5KDM4E | |
| 7-Hydroxyflavanone SCHEMBL1072683 | 0.82 | MAOB (1.00) | MAOBCYP19A1MAOAPSMB5KDM4E | |
| 7-Hydroxyflavanone SCHEMBL126599 | 0.82 | MAOB (1.00) | MAOBCYP19A1MAOAPSMB5KDM4E | |
| SCHEMBL6711965 | 0.82 | MAOB (0.69) | MAOBCYP19A1MAOAPSMB5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0139614-B1 | PHARMACEUTICAL PREPARATIONS CONTAINING FLAVANONE OR THIOFLAVANONE DERIVATIVES, THE USE THEREOF, NOVEL FLAVANONES AND THIOFLAVANONES, AND PROCESSES FOR THEIR MANUFACTURE | Zyma SA (CH) | 1990-08-22 | — | — | EP | disclosed |
| US-4935441-A | Flavene and thioflavene derivates, processes for their manufacture, pharmaceutical preparations that contain such compounds, and the use of the latter | ZYMA SA (CH) | 1990-06-19 | — | — | US | disclosed |
| US-4885298-A | Pharmaceutical preparations containing flavanone or thioflavanone derivatives the use thereof, novel flavanones and thioflavanones, and processes for their manufacture | ZYMA SA (CH) | 1989-12-05 | — | — | US | disclosed |
| EP-0139615-B1 | FLAVENE AND THIOFLAVENE DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE, PHARMACEUTICAL PREPARATIONS THAT CONTAIN SUCH COMPOUNDS, AND THE USE OF THE LATTER | Zyma SA (CH) | 1989-04-19 | — | — | EP | disclosed |
| EP-0139615-A2 | Flavene and thioflavene derivatives, processes for their manufacture, pharmaceutical preparations that contain such compounds, and the use of the latter | Zyma SA (CH) | 1985-05-02 | — | — | EP | disclosed |
| EP-0139614-A2 | Pharmaceutical preparations containing flavanone or thioflavanone derivatives, the use thereof, novel flavanones and thioflavanones, and processes for their manufacture | Zyma SA (CH) | 1985-05-02 | — | — | EP | disclosed |