Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ELANE | P08246 | 11/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
| ▸ | C1R | P00736 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2544239 | 0.83 | KDM4E (0.48) | KDM4EALDH1A1GAAMEN1POLB | |
| SCHEMBL10958443 | 0.80 | KDM4E (0.46) | KDM4EALDH1A1GAAMEN1POLB | |
| SCHEMBL10749984 | 0.78 | ELANE (0.70) | KDM4EALDH1A1ELANEMEN1POLB | |
| SCHEMBL10749503 | 0.78 | ELANE (0.71) | ELANEC1R | |
| SCHEMBL6505633 | 0.76 | ELANE (0.72) | ELANEC1R | |
| SCHEMBL3452796 | 0.76 | ELANE (0.71) | ELANE | |
| SCHEMBL15641096 | 0.74 | ELANE (0.60) | KDM4EALDH1A1ELANEMEN1POLB | |
| SCHEMBL10749480 | 0.74 | ELANE (0.67) | ELANE | |
| SCHEMBL3452649 | 0.73 | ELANE (0.68) | KDM4EALDH1A1ELANEMEN1KMT2A | |
| SCHEMBL4117968 | 0.71 | ELANE (1.00) | KDM4EALDH1A1ELANEMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147211-B1 | 4H-3,1-BENZOXAZIN-4-ONES AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | SYNTEX (U.S.A.) INC. (US) | 1990-09-12 | — | — | EP | disclosed |
| US-4657893-A | ANTIINFLAMMATORY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1987-04-14 | — | — | US | disclosed |