SCHEMBL10364449

SCHEMBL10364449

O=c1oc(NCc2ccccc2)nc2ccc(I)cc12

nearest known ligand 0.71

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ELANE P08246 13/20 0.71
C1R P00736 6/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6505439 0.87 ELANE (0.72) ELANEC1R
SCHEMBL10749503 0.84 ELANE (0.71) ELANEC1R
SCHEMBL10750509 0.83 ELANE (1.00) ELANE
SCHEMBL10748467 0.82 ELANE (0.71) ELANEC1R
SCHEMBL10748640 0.79 ELANE (0.63) ELANE
SCHEMBL10362754 0.79 ELANE (0.66) ELANEC1R
SCHEMBL10749568 0.78 ELANE (0.62) ELANE
SCHEMBL10364669 0.78 ELANE (0.73) ELANEC1R
SCHEMBL10749140 0.78 ELANE (0.68) ELANEC1R
SCHEMBL10363501 0.77 ELANE (0.71) ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0147211-B1 4H-3,1-BENZOXAZIN-4-ONES AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION SYNTEX (U.S.A.) INC. (US) 1990-09-12 EP disclosed
US-4657893-A ANTIINFLAMMATORY AGENTS SYNTEX (U.S.A.) INC. (US) 1987-04-14 US disclosed
EP-0147211-A2 4H-3,1-benzoxazin-4-ones and related compounds, pharmaceutical compositions containing them, and processes for their preparation SYNTEX (U.S.A.) INC. (US) 1985-07-03 EP disclosed