Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 4/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | SELE | P16581 | 1/20 | 0.33 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.33 |
| ▸ | ADH5 | P11766 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.32 |
| ▸ | CD38 | P28907 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10365670 | 0.91 | PDE3B (0.41) | PDE3BPDE3APDE2APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL10364606 | 0.90 | PDE3B (0.41) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10762619 | 0.85 | PDE3B (0.43) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10916775 | 0.82 | PDE3B (0.39) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10758369 | 0.82 | PDE3B (0.49) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10365557 | 0.82 | PDE3B (0.47) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10365669 | 0.81 | PDE2A (0.43) | PDE3BPDE3APDE2APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL10366384 | 0.81 | PDE3B (0.47) | PDE3BPDE3APDE2APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL10763679 | 0.81 | PDE2A (0.43) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10758959 | 0.77 | PDE3A (0.68) | PDE3BPDE3APDE2APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175187-B1 | 3,4-DIHYDRO-2(1H)-PYRIDONES AND 2(1H)-PYRIDONES CONTAINING IMIDAZOLE GROUPS, METHOD FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | A. Nattermann & Cie. GmbH (DE) | 1990-01-10 | — | — | EP | disclosed |
| EP-0175187-A1 | 3,4-Dihydro-2(1H)-pyridones and 2(1H)-pyridones containing imidazole groups, method for their preparation and medicaments containing them | A. Nattermann & Cie. GmbH (DE) | 1986-03-26 | — | — | EP | disclosed |