Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9970727 | 0.90 | CYP1A2 (0.58) | KMT2AMEN1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL18374069 | 0.89 | CYP1A2 (0.53) | KMT2ACYP1A2CYP2C19HDAC8HDAC3 | |
| SCHEMBL29387341 | 0.89 | CYP1A2 (0.53) | KMT2ACYP1A2CYP2C19HDAC8HDAC3 | |
| SCHEMBL30601912 | 0.87 | HDAC8 (0.55) | SMN1; SMN2KMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL29386458 | 0.87 | HDAC8 (0.55) | SMN1; SMN2KMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL25123844 | 0.87 | HDAC8 (0.55) | SMN1; SMN2KMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL29990582 | 0.87 | HDAC8 (0.55) | SMN1; SMN2KMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL29991896 | 0.87 | HDAC8 (0.55) | SMN1; SMN2KMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL25123876 | 0.87 | HDAC8 (0.55) | SMN1; SMN2KMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL18374697 | 0.87 | HDAC8 (0.55) | SMN1; SMN2KMT2AMEN1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166697-B1 | AROYL SUBSTITUTED DIHYDRO-1,4-THIAZINES | CIBA-GEIGY AG (CH) | 1990-05-09 | — | — | EP | disclosed |
| US-4622322-A | ANTIRHEUMATIC AGENTS | CIBA-GEIGY CORPORATION (US) | 1986-11-11 | — | — | US | disclosed |
| EP-0166697-A2 | Aroyl substituted dihydro-1,4-thiazines | CIBA-GEIGY AG (CH) | 1986-01-02 | — | — | EP | disclosed |