SCHEMBL10370889

SCHEMBL10370889

CCCC(C#N)(Cc1cccnc1)c1cccc(Cl)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.44
CYP3A4 P08684 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
HIF1A Q16665 1/20 0.39
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
HPGD P15428 1/20 0.38
NPC1 O15118 2/20 0.37
RORC P51449 1/20 0.36
P2RX7 Q99572 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
PGK1 P00558 1/20 0.35
ATM Q13315 1/20 0.35
FDPS P14324 1/20 0.35
CYP2D6 P10635 1/20 0.35
SLC6A2 P23975 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10371966 0.84 POLB (0.41) CYP19A1ALDH1A1LMNAP2RX7TDP1
SCHEMBL10369798 0.81 CYP3A4 (0.40) CYP3A4CYP1A2CYP2C9CYP2C19HIF1A
SCHEMBL10371540 0.81 NPC1 (0.41) CYP19A1CYP3A4CYP1A2CYP2C9CYP2C19
SCHEMBL10405751 0.80 CYP3A4 (0.39) CYP3A4CYP1A2CYP2C9CYP2C19HIF1A
SCHEMBL10373606 0.80 KDM4E (0.41) CYP19A1CYP3A4CYP1A2CYP2C9CYP2C19
SCHEMBL10372417 0.80 TDP1 (0.40) CYP3A4CYP1A2CYP2C9CYP2C19HIF1A
SCHEMBL10372451 0.79 TDP1 (0.45) CYP19A1CYP3A4CYP1A2CYP2C9CYP2C19
SCHEMBL10371783 0.79 CYP3A4 (0.44) CYP19A1CYP3A4CYP1A2CYP2C9CYP2C19
SCHEMBL10371878 0.77 TDP1 (0.40) CYP19A1ALDH1A1P2RX7TDP1L3MBTL1
SCHEMBL10371112 0.75 CYP3A4 (0.46) CYP19A1CYP3A4CYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0214793-B1 (2-CYANO-2-ARYLETHYL)PYRIDINES, THEIR PREPARATION AND USE AS FUNGICIDES ROHM AND HAAS COMPANY (US) 1990-06-13 EP disclosed
US-4933339-A PHYTOPATHOGENS ROHM AND HAAS COMPANY (US) 1990-06-12 US disclosed
EP-0214793-A1 (2-Cyano-2-arylethyl)pyridines, their preparation and use as fungicides ROHM AND HAAS COMPANY (US) 1987-03-18 EP disclosed