Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 7/20 | 0.40 |
| ▸ | NOS2 | P35228 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11465542 | 0.81 | KMT2A (0.40) | LMNACRHR1NOS2KMT2AKDM4E | |
| SCHEMBL10377527 | 0.78 | KDM4E (0.50) | CRHR1NOS2KMT2AKDM4EMEN1 | |
| SCHEMBL10377680 | 0.78 | SLC29A1 (0.40) | LMNACRHR1KMT2AMEN1SLC29A1 | |
| SCHEMBL5355585 | 0.74 | MAPT (0.50) | LMNACRHR1KMT2AMEN1SLC29A1 | |
| SCHEMBL1032549 | 0.74 | SLC29A1 (0.41) | LMNACRHR1KMT2AKDM4EMEN1 | |
| SCHEMBL11433990 | 0.73 | KMT2A (0.49) | LMNANOS2KMT2AKDM4EMEN1 | |
| SCHEMBL21081373 | 0.71 | MAPT (0.47) | LMNACRHR1KMT2AMEN1SLC29A1 | |
| SCHEMBL9279848 | 0.70 | KMT2A (0.44) | LMNACRHR1NOS2KMT2AKDM4E | |
| SCHEMBL6470819 | 0.70 | CDK2 (0.35) | LMNACRHR1NOS2KMT2AKDM4E | |
| SCHEMBL428397 | 0.70 | MAPT (0.42) | CRHR1KMT2AMEN1SLC29A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189045-B1 | PYRIDOPYRIMIDINES, DIFFERENT PROCESSES FOR THEIR PREPARATION AS WELL AS THEIR USE AS MEDICAMENTS | BAYER AG (DE) | 1990-02-14 | — | — | EP | disclosed |
| US-4621082-A | Pyridopyrimidines, pharmaceutical compositions and use | BAYER AKTIENGESELLSCHAFT (DE) | 1986-11-04 | — | — | US | disclosed |
| EP-0189045-A2 | Pyridopyrimidines, different processes for their preparation as well as their use as medicaments | BAYER AG (DE) | 1986-07-30 | — | — | EP | disclosed |
| US-4331805-A | OPTICAL BRIGHTENERS | CIBA-GEIGY CORPORATION (US) | 1982-05-25 | — | — | US | disclosed |
| US-4236003-A | OPTICAL BRIGHTENERS | CIBA-GEIGY CORPORATION (US) | 1980-11-25 | — | — | US | disclosed |
| US-4157443-A | OPTICAL BRIGHTENERS | CIBA-GEIGY CORPORATION (US) | 1979-06-05 | — | — | US | disclosed |