Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.49 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.49 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10375706 | 1.00 | HSP90AA1 (0.69) | HSP90AA1MAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL28884489 | 0.85 | MAPT (0.78) | HSP90AA1MAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL6292775 | 0.82 | HSP90AA1 (1.00) | HSP90AA1MAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL10375478 | 0.81 | HSP90AA1 (0.69) | HSP90AA1MAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL10375480 | 0.81 | HSP90AA1 (0.69) | HSP90AA1MAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL19509589 | 0.78 | HSP90AA1 (0.70) | HSP90AA1MAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL3397808 | 0.78 | HSP90AA1 (0.66) | HSP90AA1MAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL1933655 | 0.78 | MAPT (1.00) | HSP90AA1MAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL1933659 | 0.78 | MAPT (1.00) | HSP90AA1MAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL1822978 | 0.78 | MAPT (1.00) | HSP90AA1MAPTKDM4EALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187711-B1 | OCTAHYDROINDOLIZINE COMPOUNDS USEFUL AS ANALGESICS | McNeilab, Inc. (US) | 1990-08-29 | — | — | EP | disclosed |
| EP-0187711-A2 | Octahydroindolizine compounds useful as analgesics | McNeilab, Inc. (US) | 1986-07-16 | — | — | EP | disclosed |
| US-4582836-A | Octahydroindolizine compounds useful as analgesics | MCNEILAB, INC. (US) | 1986-04-15 | — | — | US | disclosed |