Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 18/20 | 0.73 |
| ▸ | PDE3A | Q14432 | 18/20 | 0.73 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10377813 | 0.84 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL10378694 | 0.84 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL10378903 | 0.84 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL10378892 | 0.84 | PDE3B (0.73) | PDE3BPDE3A | |
| SCHEMBL10379203 | 0.84 | PDE3B (1.00) | PDE3BPDE3ABCHE | |
| SCHEMBL10807799 | 0.84 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL2309156 | 0.84 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL10811148 | 0.84 | PDE3B (0.63) | PDE3BPDE3A | |
| SCHEMBL10378883 | 0.84 | PDE3B (1.00) | PDE3BPDE3ABCHE | |
| SCHEMBL10378576 | 0.84 | PDE3B (0.68) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0168037-B1 | 1-6-NAPHTHYRIDIN-2(1H)-ONES USEFUL AS CARDIOTONICS | STERLING DRUG INC. (US) | 1990-02-07 | — | — | EP | disclosed |
| EP-0168037-A2 | 1-6-Naphthyridin-2(1H)-ones useful as cardiotonics | STERLING DRUG INC. (US) | 1986-01-15 | — | — | EP | disclosed |
| US-4560691-A | 5-(Phenyl)-1,6-naphthyridin-2(1H)-ones, their cardiotonic use and preparation | STERLING DRUG INC. (US) | 1985-12-24 | — | — | US | disclosed |