Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.52 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7491535 | 1.00 | KMT2A (0.58) | KMT2ACYP3A4HCRTR1HCRTR2GAA | |
| SCHEMBL4573101 | 0.92 | HCRTR1 (0.56) | KMT2ACYP3A4HCRTR1HCRTR2LMNA | |
| SCHEMBL4573105 | 0.92 | HCRTR1 (0.56) | KMT2ACYP3A4HCRTR1HCRTR2LMNA | |
| SCHEMBL21869749 | 0.88 | KMT2A (0.52) | KMT2AHCRTR1HCRTR2HDAC1HDAC6 | |
| SCHEMBL17319526 | 0.88 | KMT2A (0.74) | KMT2ACYP3A4GAAKDM4EHTT | |
| SCHEMBL12471703 | 0.88 | KMT2A (0.74) | KMT2ACYP3A4GAAKDM4EHTT | |
| SCHEMBL16600994 | 0.88 | KMT2A (0.55) | KMT2AHCRTR1HCRTR2GAALMNA | |
| SCHEMBL10377856 | 0.88 | KMT2A (0.55) | KMT2AHCRTR1HCRTR2GAALMNA | |
| SCHEMBL28559505 | 0.86 | KMT2A (0.58) | KMT2AHCRTR1HCRTR2GAAMEN1 | |
| SCHEMBL28559507 | 0.86 | KMT2A (0.58) | KMT2AHCRTR1HCRTR2GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0197318-B1 | Benzo[C]-1,5-naphthyridines, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-05-09 | — | — | EP | disclosed |
| US-4742171-A | AROMATIZATION, REARRANGEMENT | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-05-03 | — | — | US | disclosed |
| US-4742061-A | Benzoc[c]-1,5-naphthyridines and related compounds as memory enhancing agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-05-03 | — | — | US | disclosed |
| US-4670562-A | MEMORY ENHANCEMENT | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-06-02 | — | — | US | disclosed |
| US-4652567-A | Benzo(c)-1,5-naphthyridines useful for treating a patient having drug induced memory impairment in need of memory enhancement | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0197318-A1 | Benzo[C]-1,5-naphthyridines, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-10-15 | — | — | EP | disclosed |