Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.40 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL478032 | 0.89 | — | — | |
| Fluoride SCHEMBL27558597 | 0.87 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| Ammonia Solution, Strong SCHEMBL28456403 | 0.87 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| Hydrochloric Acid SCHEMBL6588210 | 0.87 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| Hydrochloric Acid SCHEMBL31050781 | 0.87 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| Acetonitrile SCHEMBL28546644 | 0.78 | SMN1; SMN2 (0.44) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL6227535 | 0.75 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL29715186 | 0.73 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL29715183 | 0.73 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL7348613 | 0.72 | TSHR (0.51) | SLC6A2SLC6A4SLC6A3TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0127135-B1 | FUSED TRICYCLIC DERIVATIVES OF NAPHTHYRIDINONE AND PYRIDONE AND THE CORRESPONDING THIONES | SCHERING CORPORATION (US) | 1990-08-29 | — | — | EP | disclosed |
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |