Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1037054 | 0.87 | GRM2 (0.49) | GRM2 | |
| SCHEMBL1035619 | 0.83 | GRM2 (0.66) | GRM2 | |
| SCHEMBL2634666 | 0.82 | GRM2 (0.46) | GRM2 | |
| SCHEMBL7950081 | 0.82 | GRM2 (0.46) | GRM2 | |
| SCHEMBL1034285 | 0.81 | GRM2 (0.62) | GRM2IP6K1 | |
| SCHEMBL1038503 | 0.81 | GRM2 (0.45) | GRM2 | |
| SCHEMBL1038500 | 0.78 | GRM2 (1.00) | GRM2 | |
| SCHEMBL1039083 | 0.76 | GRM2 (1.00) | GRM2 | |
| SCHEMBL1037975 | 0.76 | GRM2 (0.66) | GRM2 | |
| SCHEMBL1035992 | 0.75 | GRM2 (1.00) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220000856-A1 | 1',3'-Disubstituted-4-Phenyl-3,4,5,6-Tetrahydro-2H,1'H-[1,4']Bipyridinyl-2'-Ones | JANSSEN PHARMACEUTICALS INC (US) | 2022-01-06 | — | — | US | disclosed |
| US-20220000856-A1 | 1',3'-Disubstituted-4-Phenyl-3,4,5,6-Tetrahydro-2H,1'H-[1,4']Bipyridinyl-2'-Ones | JANSSEN PHARMACEUTICALS INC (US) | 2022-01-06 | — | — | US | disclosed |
| US-11071729-B2 | 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′]bipyridinyl-2′-ones | ADDEX PHARMACEUTICALS S.A. (CH) | 2021-07-27 | — | — | US | disclosed |
| US-11071729-B2 | 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′]bipyridinyl-2′-ones | ADDEX PHARMACEUTICALS S.A. (CH) | 2021-07-27 | — | — | US | disclosed |
| US-20200038391-A1 | 1',3'-Disubstituted-4-Phenyl-3,4,5,6-Tetrahydro-2H,1'H-[1,4']Bipyridinyl-2'-Ones | JANSSEN PHARMACEUTICALS INC (US) | 2020-02-06 | — | — | US | disclosed |
| US-20200038391-A1 | 1',3'-Disubstituted-4-Phenyl-3,4,5,6-Tetrahydro-2H,1'H-[1,4']Bipyridinyl-2'-Ones | JANSSEN PHARMACEUTICALS INC (US) | 2020-02-06 | — | — | US | disclosed |
| US-20150336930-A1 | 1',3'-Disubstituted-4-Phenyl-3,4,5,6-Tetrahydro-2H,1'H-[1,4']Bipyridinyl-2'-Ones | JANSSEN PHARMACEUTICALS INC (US) | 2015-11-26 | — | — | US | disclosed |
| US-20150336930-A1 | 1',3'-Disubstituted-4-Phenyl-3,4,5,6-Tetrahydro-2H,1'H-[1,4']Bipyridinyl-2'-Ones | JANSSEN PHARMACEUTICALS INC (US) | 2015-11-26 | — | — | US | disclosed |
| US-9132122-B2 | 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′]bipyridinyl-2′-ones | Janssen Pharmaceuticals, Inc. (US) | 2015-09-15 | — | — | US | disclosed |
| US-9132122-B2 | 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′]bipyridinyl-2′-ones | Janssen Pharmaceuticals, Inc. (US) | 2015-09-15 | — | — | US | disclosed |
| US-20130197019-A1 | 1',3'-DISUBSTITUTED-4-PHENYL-3,4,5,6-TETRAHYDRO-2H,1'H-[1,4']BIPYRIDINYL-2'-ONES | ADDEX PHARMACEUTICALS S.A (CH) | 2013-08-01 | — | — | US | disclosed |
| US-20130197019-A1 | 1',3'-DISUBSTITUTED-4-PHENYL-3,4,5,6-TETRAHYDRO-2H,1'H-[1,4']BIPYRIDINYL-2'-ONES | ADDEX PHARMACEUTICALS S.A (CH) | 2013-08-01 | — | — | US | disclosed |
| US-20130196992-A1 | 1',3'-DISUBSTITUTED-4-PHENY-3,4,5,6-TETRAHYDRO-2H,1'H-[1,4']BIPYRIDINYL-2'-ONES | ADDEX PHARMACEUTICALS S.A (CH) | 2013-08-01 | — | — | US | disclosed |
| US-20130197019-A1 | 1',3'-DISUBSTITUTED-4-PHENYL-3,4,5,6-TETRAHYDRO-2H,1'H-[1,4']BIPYRIDINYL-2'-ONES | ADDEX PHARMACEUTICALS S.A (CH) | 2013-08-01 | — | — | US | disclosed |
| EP-2203439-B1 | 1',3'-DISUBSTITUTED-4-PHENYL-3,4,5,6-TETRAHYDRO-2H, 1'H-Ý1, 4'¨BIPYRIDINYL-2'-ONES | ORTHO MCNEIL JANSSEN PHARM (US) | 2011-01-26 | — | — | EP | disclosed |
| EP-2203439-B1 | 1',3'-DISUBSTITUTED-4-PHENYL-3,4,5,6-TETRAHYDRO-2H, 1'H-Ý1, 4'¨BIPYRIDINYL-2'-ONES | ORTHO MCNEIL JANSSEN PHARM (US) | 2011-01-26 | — | — | EP | disclosed |
| US-20100240688-A1 | 1,3-DISUBSTITUTED-4-PHENYL-3,4,5,6-TETRAHYDRO-2H,1 H-1,4 BIPYRIDINYL-2-ONES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| US-20100240688-A1 | 1,3-DISUBSTITUTED-4-PHENYL-3,4,5,6-TETRAHYDRO-2H,1 H-1,4 BIPYRIDINYL-2-ONES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| US-20100240688-A1 | 1,3-DISUBSTITUTED-4-PHENYL-3,4,5,6-TETRAHYDRO-2H,1 H-1,4 BIPYRIDINYL-2-ONES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| WO-2009033704-A1 | 1',3'-DISUBSTITUTED-4-PHENYL-3,4,5,6-TETRAHYDRO-2H, 1'H-[1, 4'] BIPYRIDINYL-2'-ONES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11071729-B2 | 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′]bipyridinyl-2′-ones | GRM2, GRM1, GRIN2C | GRM2 1/4885IP6K1 657/4885 |
| US-20220000856-A1 | 1',3'-Disubstituted-4-Phenyl-3,4,5,6-Tetrahydro-2H,1'H-[1,4']Bipyridinyl-2'-Ones | GRM2, GRM1, GRIN2C | GRM2 1/4885IP6K1 665/4885 |
| US-20130197019-A1 | 1',3'-DISUBSTITUTED-4-PHENYL-3,4,5,6-TETRAHYDRO-2H,1'H-[1,4']BIPYRIDINYL-2'-ONES | GRM2, GRM1, GRIN2C | GRM2 1/4885IP6K1 664/4885 |
| US-20200038391-A1 | 1',3'-Disubstituted-4-Phenyl-3,4,5,6-Tetrahydro-2H,1'H-[1,4']Bipyridinyl-2'-Ones | GRM2, GRM1, GRIN2C | GRM2 1/4885IP6K1 665/4885 |
| US-20130196992-A1 | 1',3'-DISUBSTITUTED-4-PHENY-3,4,5,6-TETRAHYDRO-2H,1'H-[1,4']BIPYRIDINYL-2'-ONES | GRM2, GRM1, GRM3 | GRM2 1/4885IP6K1 672/4885 |
| US-20100240688-A1 | 1,3-DISUBSTITUTED-4-PHENYL-3,4,5,6-TETRAHYDRO-2H,1 H-1,4 BIPYRIDINYL-2-ONES | GRM2, GRM1, GRM3 | GRM2 1/4885IP6K1 561/4885 |
| US-20150336930-A1 | 1',3'-Disubstituted-4-Phenyl-3,4,5,6-Tetrahydro-2H,1'H-[1,4']Bipyridinyl-2'-Ones | GRM2, GRM1, GRIN2C | GRM2 1/4885IP6K1 665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.