Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 15/20 | 0.56 |
| ▸ | SCN2B | O60939 | 10/20 | 0.43 |
| ▸ | SCN1B | Q07699 | 10/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 8/20 | 0.43 |
| ▸ | SCN1A | P35498 | 7/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10324725 | 0.84 | SCN9A (0.67) | SCN9ASCN2BSCN1BSCN5ASCN1A | |
| SCHEMBL10325019 | 0.83 | SCN9A (0.61) | SCN9ASCN2BSCN1BSCN5ASCN1A | |
| SCHEMBL10380538 | 0.79 | SCN9A (0.73) | SCN9ASCN2BSCN1BSCN5ASCN1A | |
| SCHEMBL10379580 | 0.78 | SCN9A (0.79) | SCN9ASCN2BSCN1BSCN5ASCN1A | |
| SCHEMBL10380145 | 0.77 | SCN9A (0.58) | SCN9ASCN2BSCN1BSCN5ASCN1A | |
| SCHEMBL10324443 | 0.77 | SCN9A (0.70) | SCN9ASCN2BSCN1BSCN5ASCN1A | |
| SCHEMBL10379940 | 0.77 | SCN9A (0.67) | SCN9ASCN2BSCN1BSCN5ASCN1A | |
| SCHEMBL10379494 | 0.76 | SCN9A (0.79) | SCN9ASCN2BSCN1BSCN5ASCN1A | |
| SCHEMBL10379433 | 0.72 | SCN9A (0.73) | SCN9ASCN2BSCN1BSCN5ASCN1A | |
| Pf-05241328 SCHEMBL10324699 | 0.72 | SCN9A (1.00) | SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012095781-A1 | INDAZOLE DERIVATIVES AS SODIUM CHANNEL INHIBITORS | PFIZER LIMITED (GB) | 2012-07-19 | — | — | WO | disclosed |