Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.51 |
| ▸ | TFEB | P19484 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10383309 | 1.00 | KDM4E (0.65) | KDM4ELMNAMAPTKMT2ACYP3A4 | |
| SCHEMBL9402733 | 0.88 | PTGER1 (0.59) | KDM4ELMNAMAPTKMT2ACYP3A4 | |
| SCHEMBL242465 | 0.88 | PTGER1 (0.59) | KDM4ELMNAMAPTKMT2ACYP3A4 | |
| SCHEMBL9717006 | 0.88 | PTGER1 (0.59) | KDM4ELMNAMAPTKMT2ACYP3A4 | |
| SCHEMBL4331860 | 0.88 | PTGER1 (0.59) | KDM4ELMNAMAPTKMT2ACYP3A4 | |
| SCHEMBL9716995 | 0.88 | PTGER1 (0.59) | KDM4ELMNAMAPTKMT2ACYP3A4 | |
| SCHEMBL4331862 | 0.88 | PTGER1 (0.59) | KDM4ELMNAMAPTKMT2ACYP3A4 | |
| SCHEMBL8092292 | 0.88 | PTGER1 (0.59) | KDM4ELMNAMAPTKMT2ACYP3A4 | |
| SCHEMBL9716933 | 0.88 | PTGER1 (0.59) | KDM4ELMNAMAPTKMT2ACYP3A4 | |
| SCHEMBL7096424 | 0.88 | PTGER1 (0.59) | KDM4ELMNAMAPTKMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4894480-A | Phenyl substituted-2,4,6,8-nonatetraenoic acid | HOFFMANN-LA ROCHE INC. (US) | 1990-01-16 | — | — | US | disclosed |
| US-4883613-A | TREATMENT OF RHEUMATOID ARTHRITIS, IMMUNOSUPPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1989-11-28 | — | — | US | disclosed |
| US-4883614-A | TREATMENT OF RHEUMATOID ARTHRITIS, IMMUNOSUPPRESSANTS | HOFFMAN-LA ROCHE INC. (US) | 1989-11-28 | — | — | US | disclosed |
| US-4780251-A | ANTIRHEUMATIC AGENTS, IMMUNOSUPPRESSANTS | HOFFMAN-LA ROCHE INC. (US) | 1988-10-25 | — | — | US | disclosed |
| EP-0169571-B1 | PHENYLNONATETRAENIC-ACID DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1988-03-09 | — | — | EP | disclosed |
| US-4648996-A | ANTIRHEUMATIC AGENTS, IMMUNOSUPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1987-03-10 | — | — | US | disclosed |
| EP-0169571-A1 | Phenylnonatetraenic-acid derivatives, their preparation and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1986-01-29 | — | — | EP | disclosed |