Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | GLB1 | P16278 | 2/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 4/20 | 0.31 |
| ▸ | PYGL | P06737 | 1/20 | 0.31 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9484397 | 1.00 | CXCR4 (0.41) | CXCR4GLB1LTA4HPARP1GBA1 | |
| SCHEMBL4743019 | 0.98 | — | — | |
| SCHEMBL219819 | 0.98 | — | — | |
| SCHEMBL4749933 | 0.98 | — | — | |
| Hydrochloric Acid SCHEMBL22122712 | 0.95 | CXCR4 (0.38) | CXCR4GLB1LTA4HPARP1 | |
| Hydrochloric Acid SCHEMBL30460597 | 0.95 | CXCR4 (0.38) | CXCR4GLB1LTA4HPARP1 | |
| Piperazine SCHEMBL11673759 | 0.87 | CXCR4 (0.46) | CXCR4LTA4HPARP1 | |
| SCHEMBL19878848 | 0.84 | CXCR4 (0.47) | CXCR4GLB1 | |
| SCHEMBL2916370 | 0.84 | CXCR4 (0.47) | CXCR4GLB1 | |
| SCHEMBL1408398 | 0.84 | CXCR4 (0.44) | CXCR4LTA4HPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4946612-A | Lubricating oil composition for sliding surface and for metallic working and method for lubrication of machine tools using said composition | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1990-08-07 | — | — | US | disclosed |