Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ACE | P12821 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | REN | P00797 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PEPD | P12955 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10404111 | 0.91 | SMN1; SMN2 (0.64) | POLBSMN1; SMN2HSD17B10ACELMNA | |
| SCHEMBL11429878 | 0.88 | POLB (0.62) | POLBSMN1; SMN2ACELMNA | |
| SCHEMBL11426920 | 0.87 | POLB (0.61) | POLBSMN1; SMN2HSD17B10ACELMNA | |
| SCHEMBL11427504 | 0.87 | POLB (0.61) | POLBSMN1; SMN2TSHRACELMNA | |
| Water SCHEMBL11499705 | 0.86 | POLB (0.60) | POLBSMN1; SMN2HSD17B10ACELMNA | |
| Water SCHEMBL11499395 | 0.86 | POLB (0.60) | POLBSMN1; SMN2TSHRACELMNA | |
| SCHEMBL11518887 | 0.86 | SMN1; SMN2 (0.60) | POLBSMN1; SMN2HSD17B10TSHRHTT | |
| SCHEMBL11429868 | 0.85 | TSHR (0.64) | POLBSMN1; SMN2HSD17B10TSHRHTT | |
| Water SCHEMBL11435614 | 0.84 | TSHR (0.63) | POLBSMN1; SMN2HSD17B10TSHRHTT | |
| SCHEMBL10403464 | 0.83 | SMN1; SMN2 (0.56) | POLBSMN1; SMN2HSD17B10ACELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4971993-A | HYPOTENSIVE DIPEPTIDES DERIVATIVES | AJINOMOTO CO., INC. (JP) | 1990-11-20 | — | — | US | claimed |
| US-4187216-A | ELASTASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1980-02-05 | — | — | US | claimed |
| US-4971993-A | HYPOTENSIVE DIPEPTIDES DERIVATIVES | AJINOMOTO CO., INC. (JP) | 1990-11-20 | — | — | US | disclosed |
| EP-0190852-A2 | Dipeptide derivatives and antihypertensive drugs containing them | AJINOMOTO CO., INC. (JP) | 1986-08-13 | — | — | EP | disclosed |
| US-4187216-A | ELASTASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1980-02-05 | — | — | US | disclosed |