Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.53 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.45 |
| ▸ | MAP3K14 | Q99558 | 9/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15663271 | 0.93 | PIK3CA (0.62) | PIK3CAPIK3C3PIK3CDPIK3CBPIK3CG | |
| SCHEMBL15663311 | 0.84 | PIK3CA (0.42) | PIK3CAMAP3K14PIK3CDPIK3R1PIK3CB | |
| SCHEMBL989573 | 0.84 | PIK3CA (0.54) | PIK3CAPIK3C3MAP3K14PIK3CDPIK3R1 | |
| SCHEMBL15663385 | 0.83 | PIK3CA (0.57) | PIK3CAPIK3C3MAP3K14PIK3CDPIK3CB | |
| SCHEMBL15663284 | 0.80 | PIK3CA (0.41) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1083123 | 0.79 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL988697 | 0.79 | PIK3CA (0.41) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1620834 | 0.79 | PIK3CA (0.48) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL15663283 | 0.78 | PIK3CA (0.56) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL15663282 | 0.77 | PIK3CA (0.49) | PIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-B1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH INC (US) | 2014-05-07 | — | — | EP | claimed |
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | claimed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | claimed |