Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.38 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1040622 | 0.94 | PIK3CA (0.53) | PIK3CAPIK3C3PIK3CBPIK3CDPIK3CG | |
| SCHEMBL1041109 | 0.89 | PIK3CA (0.56) | PIK3CAPIK3C3PIK3CBPIK3CDPIK3CG | |
| SCHEMBL4112183 | 0.86 | PIK3CA (0.47) | PIK3CAPIK3C3PIK3CBNPY5RPIK3CD | |
| SCHEMBL1484912 | 0.83 | PIK3CA (0.69) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1619994 | 0.82 | PIK3CA (0.46) | PIK3CAPIK3C3PIK3CBNPY5RPIK3CD | |
| SCHEMBL1043239 | 0.82 | PIK3CA (0.66) | PIK3CAPIK3C3PIK3CBPIK3CDPIK3CG | |
| SCHEMBL4116437 | 0.80 | PIK3CA (0.55) | PIK3CAPIK3C3PIK3CBPIK3CDPIK3CG | |
| SCHEMBL1042898 | 0.79 | PIK3CA (0.47) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1042374 | 0.76 | PIK3CA (0.57) | PIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1620373 | 0.76 | PIK3CA (0.54) | PIK3CAPIK3C3PIK3CBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110130363-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2011-06-02 | — | — | US | claimed |
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | claimed |
| US-9309265-B2 | Benzopyran and benzoxepin PI3K inhibitor compounds and methods of use | GENENTECH, INC. (US) | 2016-04-12 | — | — | US | disclosed |
| US-20140336154-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | HOFFMANN-LA ROCHE INC. | 2014-11-13 | — | — | US | disclosed |
| US-20110130363-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2011-06-02 | — | — | US | disclosed |
| US-7928248-B2 | Benzopyran and benzoxepin PI3K inhibitor compounds and methods of use | GENENTECH, INC. (US) | 2011-04-19 | — | — | US | disclosed |
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140336154-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | PIK3CA, BMX, PIK3CD | PIK3CA 1/4885PIK3C3 27/4885PIK3CB 9/4885 |
| US-20110130363-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | PIK3CA, BMX, PIK3CD | PIK3CA 1/4885PIK3C3 27/4885PIK3CB 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.