SCHEMBL10409227

SCHEMBL10409227

COC([CH]Cc1ccccc1)(OC)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.41
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
MAPK1 P28482 1/20 0.34
LTA4H P09960 1/20 0.34
CES1 P23141 1/20 0.34
KCNN4 O15554 1/20 0.33
TP53 P04637 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
ARG2 P78540 1/20 0.33
HTT P42858 1/20 0.33
TAAR1 Q96RJ0 2/20 0.32
ALDH1A1 P00352 2/20 0.32
ALOX15 P16050 1/20 0.32
SLC6A2 P23975 1/20 0.32
TSHR P16473 1/20 0.32
GAA P10253 1/20 0.32
KDM4E B2RXH2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5572358 0.74 MAOB (0.46) MAOBCYP1A2CYP2C9CYP2C19MAPK1
SCHEMBL6745723 0.74 MAOB (0.46) MAOBCYP1A2CYP2C9CYP2C19MAPK1
SCHEMBL9578553 0.71 MAPK1 (0.39) MAPK1CES1KCNN4HTTTAAR1
SCHEMBL3723944 0.71 CES1 (0.42) CYP2C19MAPK1CES1KCNN4ALDH1A1
SCHEMBL315315 0.70 MAOB (0.52) MAOBCYP1A2TP53CA1CA2
SCHEMBL7776201 0.68 MAPK1 (0.37) MAPK1CES1KCNN4HTTTAAR1
Phenylacetaldehyde SCHEMBL28634753 0.68 MAOB (0.44) MAOBCYP1A2CYP2C9CYP2C19LTA4H
SCHEMBL29274189 0.68 MAOB (0.45) MAOBCYP1A2CYP2C9CYP2C19MAPK1
SCHEMBL23524584 0.66 MAOB (0.52) MAOBTP53CA1CA2ARG2
SCHEMBL5088767 0.66 SLC6A2 (0.50) CYP1A2CYP2C9CYP2C19LTA4HTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4952598-A CALCIUM ANTAGONISTS HOECHST AKTIENGESELLSCHAFT (DE) 1990-08-28 US claimed