SCHEMBL10410050

SCHEMBL10410050

Cc1nc(C)c(/C=C/C(O)CC(O)CC(=O)O)c(-c2ccc(F)cc2)n1

nearest known ligand 0.60

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 13/20 0.60
NR1I2 O75469 2/20 0.60
PDE4D Q08499 2/20 0.60
ALDH1A1 P00352 1/20 0.60
CYP3A4 P08684 1/20 0.60
PDE6D O43924 1/20 0.60
ESR1 P03372 1/20 0.55
CHRM1 P11229 1/20 0.55
TBXA2R P21731 1/20 0.55
PDE4A P27815 1/20 0.55
ADRA1A P35348 1/20 0.55
NR4A2 P43354 1/20 0.52
ABCC3 O15438 1/20 0.49
ABCC4 O15439 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6238583 1.00 HMGCR (0.60) HMGCRNR1I2PDE4DALDH1A1CYP3A4
SCHEMBL6238573 1.00 HMGCR (0.60) HMGCRNR1I2PDE4DALDH1A1CYP3A4
SCHEMBL27332535 1.00 HMGCR (0.60) HMGCRNR1I2PDE4DALDH1A1CYP3A4
SCHEMBL10410052 1.00 HMGCR (0.60) HMGCRNR1I2PDE4DALDH1A1CYP3A4
SCHEMBL10557745 1.00 HMGCR (0.60) HMGCRNR1I2PDE4DALDH1A1CYP3A4
SCHEMBL6242951 0.88 HMGCR (0.56) HMGCRNR1I2PDE4DALDH1A1CYP3A4
SCHEMBL10554120 0.88 HMGCR (0.56) HMGCRNR1I2PDE4DALDH1A1CYP3A4
SCHEMBL6242954 0.88 HMGCR (0.56) HMGCRNR1I2PDE4DALDH1A1CYP3A4
SCHEMBL10411666 0.88 HMGCR (0.56) HMGCRNR1I2PDE4DALDH1A1CYP3A4
SCHEMBL10411667 0.88 HMGCR (0.56) HMGCRNR1I2PDE4DALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4929620-A ANTILIPEMIC AGENTS WARNER-LAMBERT COMPANY (US) 1990-05-29 US disclosed
US-4868185-A HYPOLIPIDEMIC, ANTICHOLESTEROL WARNER-LAMBERT COMPANY (US) 1989-09-19 US disclosed