Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328073 | 1.00 | MAPT (0.40) | MAPTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL19900531 | 0.84 | MAPT (0.34) | MAPTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL20494834 | 0.84 | MAPT (0.34) | MAPTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL19898551 | 0.84 | MAPT (0.34) | MAPTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL19900539 | 0.84 | MAPT (0.34) | MAPTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL19898973 | 0.84 | MAPT (0.34) | MAPTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL20495587 | 0.84 | MAPT (0.34) | MAPTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL20494822 | 0.84 | MAPT (0.34) | MAPTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL13748816 | 0.83 | SMYD2 (0.39) | SMYD2MGAM | |
| SCHEMBL23327126 | 0.81 | CHRM2 (0.35) | MAPTCHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4902684-A | Benzazepine and benzothiazepine derivatives | E. R. SQUIBB & SONS, INC. (US) | 1990-02-20 | — | — | US | disclosed |