Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 19/20 | 0.76 |
| ▸ | GSK3B | P49841 | 11/20 | 0.76 |
| ▸ | PRKACA | P17612 | 10/20 | 0.61 |
| ▸ | HIPK2 | Q9H2X6 | 10/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.61 |
| ▸ | PIM1 | P11309 | 9/20 | 0.61 |
| ▸ | CDK2 | P24941 | 9/20 | 0.61 |
| ▸ | DAPK3 | O43293 | 7/20 | 0.61 |
| ▸ | PAK4 | O96013 | 7/20 | 0.61 |
| ▸ | PRKX | P51817 | 7/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.61 |
| ▸ | MELK | Q14680 | 7/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.61 |
| ▸ | CDK9 | P50750 | 7/20 | 0.61 |
| ▸ | MAP4K2 | Q12851 | 6/20 | 0.61 |
| ▸ | STK3 | Q13188 | 6/20 | 0.61 |
| ▸ | MINK1 | Q8N4C8 | 6/20 | 0.61 |
| ▸ | MAP4K5 | Q9Y4K4 | 6/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 6/20 | 0.61 |
| ▸ | FLT3 | P36888 | 6/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL993049 | 0.92 | CDC7 (0.76) | CDC7GSK3BPRKACAHIPK2ROCK2 | |
| SCHEMBL1044886 | 0.90 | CDC7 (0.76) | CDC7GSK3BPRKACAHIPK2ROCK2 | |
| SCHEMBL1043046 | 0.89 | CDC7 (0.74) | CDC7GSK3BPRKACAHIPK2ROCK2 | |
| SCHEMBL1045417 | 0.88 | CDC7 (0.82) | CDC7GSK3BPRKACAHIPK2ROCK2 | |
| SCHEMBL15190316 | 0.88 | CDC7 (0.82) | CDC7GSK3BPRKACAHIPK2ROCK2 | |
| SCHEMBL1046067 | 0.88 | CDC7 (0.94) | CDC7GSK3BPRKACAHIPK2ROCK2 | |
| SCHEMBL1046354 | 0.88 | CDC7 (0.72) | CDC7GSK3BPRKACAHIPK2ROCK2 | |
| SCHEMBL1042565 | 0.87 | CDC7 (0.81) | CDC7GSK3BPRKACAHIPK2ROCK2 | |
| SCHEMBL1047127 | 0.87 | CDC7 (0.81) | CDC7GSK3BPRKACAHIPK2ROCK2 | |
| SCHEMBL1043587 | 0.87 | CDC7 (1.00) | CDC7GSK3BPRKACAHIPK2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454257-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | claimed |
| WO-2011008915-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | WO | claimed |
| WO-2011008915-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | WO | disclosed |