Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6502449 | 0.85 | TSHR (0.60) | TSHRL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL10509321 | 0.85 | TSHR (0.55) | TSHRL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7188801 | 0.85 | TSHR (0.60) | TSHRL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL26794544 | 0.82 | TSHR (0.52) | TSHRL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9121702 | 0.77 | TSHR (0.59) | TSHRL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2026026 | 0.77 | TSHR (0.63) | TSHRL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9799560 | 0.77 | TSHR (0.63) | TSHRL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5194137 | 0.76 | TSHR (0.57) | TSHRL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9019003 | 0.76 | TSHR (0.62) | TSHRL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2026600 | 0.75 | TSHR (0.61) | TSHRL3MBTL1MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4973704-A | ANTICHOLESTEROL AGENTS | SANDOZ PHARM. CORP. (US) | 1990-11-27 | — | — | US | disclosed |
| US-4851427-A | INHJIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANDOZ PHARM. CORP. (US) | 1989-07-25 | — | — | US | disclosed |
| WO-1987002662-A2 | HETEROCYCLIC ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS | SANDOZ AG (CH) | 1987-05-07 | — | — | WO | disclosed |
| EP-0221025-A1 | Heterocyclic analogs of mevalonolactone and derivatives thereof, processes for their production and their use as pharmaceuticals | SANDOZ AG (CH) | 1987-05-06 | — | — | EP | disclosed |