Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.51 |
| ▸ | PGR | P06401 | 3/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.46 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551223 | 0.84 | AHR (0.49) | AHRPGRMAOBPDE3BPDE3A | |
| SCHEMBL8670836 | 0.81 | AHR (0.59) | AHRPGRMAOBPDE3BPDE3A | |
| Potassium Ion SCHEMBL7036515 | 0.81 | GSK3B (0.46) | AHRPGRMAOBPDE3BPDE3A | |
| SCHEMBL260951 | 0.78 | AHR (0.56) | AHRPGRMAOBPDE3BPDE3A | |
| SCHEMBL22636513 | 0.78 | AHR (0.56) | AHRPGRMAOBPDE3BPDE3A | |
| SCHEMBL24570672 | 0.78 | AHR (0.61) | AHRPGRMAOBPDE3BPDE3A | |
| SCHEMBL1681854 | 0.78 | AHR (0.56) | AHRPGRMAOBPDE3BPDE3A | |
| SCHEMBL260278 | 0.78 | AHR (0.56) | AHRPGRMAOBPDE3BPDE3A | |
| SCHEMBL9435130 | 0.78 | AHR (0.56) | AHRPGRMAOBPDE3BPDE3A | |
| SCHEMBL578518 | 0.78 | AHR (0.56) | AHRPGRMAOBPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4977153-A | BETA ADRENOCEPTOR BLOCKING AGENTS | Louis, William J. (AU) | 1990-12-11 | — | — | US | disclosed |
| EP-0221958-A4 | 3-AMINOPROPYLOXYPHENYL DERIVATIVES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | LOUIS WILLIAM JOHN (AU) | 1987-11-25 | — | — | EP | disclosed |
| EP-0221958-A1 | 3-AMINOPROPYLOXYPHENYL DERIVATIVES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | LOUIS WILLIAM JOHN (AU) | 1987-05-20 | — | — | EP | disclosed |
| WO-1986006717-A1 | 3-AMINOPROPYLOXYPHENYL DERIVATIVES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LOUIS WILLIAM JOHN (AU) | 1986-11-20 | — | — | WO | disclosed |