Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA2 | Q15349 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10422349 | 1.00 | RPS6KA2 (0.35) | RPS6KA2L3MBTL1MEN1KDM4AALDH1A1 | |
| SCHEMBL23830079 | 0.80 | MAOB (0.50) | L3MBTL1MEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL10421307 | 0.80 | MAOB (0.50) | L3MBTL1MEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL10421305 | 0.80 | MAOB (0.50) | L3MBTL1MEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL10423122 | 0.75 | RPS6KA2 (0.50) | RPS6KA2L3MBTL1MEN1ALDH1A1KMT2A | |
| SCHEMBL10423125 | 0.75 | RPS6KA2 (0.50) | RPS6KA2L3MBTL1MEN1ALDH1A1KMT2A | |
| SCHEMBL10421569 | 0.74 | GAA (0.45) | MEN1ALDH1A1MAPTKMT2ACYP1A2 | |
| SCHEMBL10421904 | 0.74 | CYP1B1 (0.42) | RPS6KA2L3MBTL1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL10421571 | 0.74 | GAA (0.45) | MEN1ALDH1A1MAPTKMT2ACYP1A2 | |
| SCHEMBL10421902 | 0.74 | CYP1B1 (0.42) | RPS6KA2L3MBTL1ALDH1A1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4933325-A | ANALGESICS, HYPOTENSIVE AGENTS | G. D. SEARLE & CO. (US) | 1990-06-12 | — | — | US | disclosed |
| US-4880829-A | ANALGESICS, HYPOTENSIVE AGENTS | G. D. SEARLE AND COMPANY (US) | 1989-11-14 | — | — | US | disclosed |
| US-4822775-A | ANALGESICS | G. D. SEARLE & CO. (US) | 1989-04-18 | — | — | US | disclosed |
| EP-0215297-A2 | Substituted dipeptide amides | G.D. Searle & Co. (US) | 1987-03-25 | — | — | EP | disclosed |