Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SQLE | Q14534 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10423944 | 1.00 | SQLE (0.47) | SQLEKMT2ALSSMAPTMEN1 | |
| SCHEMBL11442813 | 0.94 | SQLE (0.48) | SQLEKMT2ALSSMAPTMEN1 | |
| SCHEMBL11123853 | 0.92 | LSS (0.48) | SQLEKMT2ALSSMAPTMEN1 | |
| SCHEMBL11123843 | 0.92 | LSS (0.48) | SQLEKMT2ALSSMAPTMEN1 | |
| SCHEMBL962044 | 0.87 | — | — | |
| SCHEMBL962046 | 0.87 | — | — | |
| SCHEMBL10593741 | 0.83 | KMT2A (0.50) | SQLEKMT2AMAPTMEN1CYP3A4 | |
| SCHEMBL10593739 | 0.83 | KMT2A (0.50) | SQLEKMT2AMAPTMEN1CYP3A4 | |
| SCHEMBL10669963 | 0.82 | SQLE (0.46) | SQLEKMT2AMAPTMEN1CYP3A4 | |
| SCHEMBL10669969 | 0.82 | SQLE (0.46) | SQLEKMT2AMAPTMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4980371-A | TREATMENT OF HIV INFECTIONS/LEUKEMIA; ANTITUMOR AGENTS, ANTICARCINOGENIC AGENTS | MERRELL DOW PHARMACEUTICALS (US) | 1990-12-25 | — | — | US | disclosed |
| EP-0374886-A2 | Antiretroviral furan ketones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-06-27 | — | — | EP | disclosed |